A Bose gas in fast rotation normally exhibits a growing number of vortices of unit strength if the angular velocity is increased. In an anharmonic trap at sufficiently high velocity, however, a phase transition is expected: Vortices in the bulk should disappear and all vorticity become concentrated in a region where the density is very low. Moreover, the critical velocity for the transition is expected to increase with on the interaction strength in a definite manner. In the lecture rigorous results on this behavior within two-dimensional Gross-Pitaevskii theory will be presented. This is joint work with Michele Correggi and Nicolas Rougerie.