Feedback, Lineages and Cancer

Monday, October 25, 2010 -
4:00pm to 6:00pm
A multispecies continuum model is developed to simulate the dynamics of cell lineages in solid tumors. The model accounts for spatiotemporally varying cell proliferation and death mediated by the heterogeneous distribution of oxygen and soluble chemical factors. Together, these regulate the rates of self-renewal and differentiation of the different cells within the lineages. As demonstrated in the talk, the feedback processes are found to play a critical role in tumor progression and the development of morphological instability.
John Lowengrub
University of California - Irvine
Event Location: 
Fine Hall 214